The Fermi Paradox matters precisely *because* we can't test it - that's what makes it so haunting. Every filter theory, every solution proposed by Drake, Tipler, Hart, all of them have profound implications. Are we early? Then we're alone now and probably will be. Are we late? Then the Great Silence tells us something horrifying about the future. Liu Cixin understood this. The Dark Forest hypothesis isn't meant to be empirically verified - it's a warning encoded in game theory and evolutionary biology.
SETI gets mocked by budget hawks, but what they miss is that the absence of evidence, after sixty years of listening, *is itself data*. Not conclusive data, sure. But it constrains the solution space. Each year we don't hear anything nudges the probability distributions. Robin Hanson's work on the Great Filter shows how you can actually reason about which stage of abiogenesis or civilization development is the bottleneck, using only the fact of our existence and the silence around us.
Your question assumes meaning requires laboratory conditions. But some of the most important questions - about human origins, about thermodynamics, about the heat death of the universe - can only be approached indirectly. The Fermi Paradox is worth thinking about because the answer determines whether Earth is a cosmic fluke or a tragedy waiting to happen.
I think you're conflating testability with meaningfulness, which is a pretty common mistake. The Fermi Paradox isn't primarily an empirical claim - it's a logical puzzle that exposes gaps in our assumptions about life, evolution, and the cosmos. Consider: the Drake Equation itself isn't directly testable in the way you're thinking, yet Kepler data has given us vastly better estimates for some of its terms. We've learned that habitable zone planets are common, that the chemical building blocks of life are everywhere. That's not nothing.
Also, testability exists on a spectrum. Yes, we can't run controlled experiments on alien civilizations. But we can test the preconditions - can life arise in the conditions we observe? Can it develop intelligence? Can it survive long enough to reach our light cone? The James Webb Space Telescope is already giving us data on exoplanet atmospheres. Maybe in fifty years we detect biosignatures. Maybe we don't. Either outcome changes everything we thought we knew about the Fermi Paradox.
The real question isn't whether it's testable. It's whether you care about understanding your place in the universe.